Fourteen participating teams engineered Dicty and HL60 cells to run through the mazes. More than 400 cells finished the race in the 3-hour observation time. HL60 cells were overall twice as fast as Dicty cells. However, Dicty cells were better at finding the shortest path through the maze.
The winner cells were Dicty cells modified for higher sensitivity to shallow gradients, through over-expression of Ric8 protein. Runner-up were HL60 cells with increased contractility and speed by overexpression of the light chain of myosin II.
SECOND PLACE 2014:
Link to the PLOS One paper when it becomes available on June 22.